Genetic Disorders: Narrowing down on Multi-Gene Research

So far, the global research statistics of genetic disorders clearly display that multi-gene research is the need of the hour. That doesn’t mean we completely sidelines or marginalize the single-gene transmitted disorders like X-Linked Recessive or those that fall under the categories of mitochondrial transmission, Y-linked disorders or Autosomal disorders and so on. Ever since biotech studies took the forefront at global forums, systematic research has unveiled significant facts about single-gene, genetically-transmitted disorders like Huffington’s Disease, Galactosemia, Genetic Spherocytosis, Polycystic Kidney Disorder, Polycystic Ovarian Disorder, Cystic Fibrosis, Hemophilia, and Hereditary Muscular Dystrophy. Apart from the ones named, several other rare genetic disorders have been brought under the lens, and the ones which were considered absolutely incurable earlier, have now unleashed a new ray of hope from the biomedical fraternity. However, a lot still needs to be done as far as multi-genetic disorders such as Metabolic Syndrome, Type 1 Diabetes, Cancer, Asthma, Hypertension, Obesity, Constipation (and various other bowel syndromes) and cleft palate are concerned.

Changing Approach to Genetic Epidemiology

As we approach the various challenges on the medical front that confront the human race in the 21st century, we get to realize that there is a great deal of work that remains pending, and a whole realm out there which remains completely unexplored. In such a scenario, it would be apt to begin by introspecting our past and present approach to Genetic Epidemilogy, and revamp the same as and where required. Of course the changes have to be rational, well-structured and systematic, but consistency is a big requirement in this regard. So far, we have taken a single-pronged approach to Genetic Epidemiology, wherein the part played by genetics in determining health of family-trees, sub-populations and sub-populations is studied, taking into account the larger picture. Today’s times require us to take a specialized approach in closely studying the interplay between genetics and the environment, how they are interdependent, inter-linked and have been playing with each other over the course of evolution.